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Mitochondrial DNA oxidation and manganese superoxide dismutase activity in peripheral blood mononuclear cells from type 2 diabetic patients

✍ Scribed by M. García-Ramírez; G. Francisco; E. García-Arumí; C. Hernández; R. Martínez; A.L. Andreu; R. Simó


Book ID
116404717
Publisher
Masson Editeur
Year
2008
Tongue
French
Weight
312 KB
Volume
34
Category
Article
ISSN
1262-3636

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## Abstract Poly(ADP‐ribose)polymerase (PARP‐1), a nuclear enzyme activated by DNA strand breaks, is involved in DNA repair, aging, inflammation, and neoplastic transformation. In diabetes, reactive oxygen and nitrogen species occurring in response to hyperglycemia cause DNA damages and PARP‐1 acti