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Mitochondrial DNA heteroplasmy in cloned cattle produced by fetal and adult cell cloning

✍ Scribed by Steinborn, Ralf; Schinogl, Pamela; Zakhartchenko, Valeri; Achmann, Roland; Schernthaner, Wolfgang; Stojkovic, Miodrag; Wolf, Eckhard; Müller, Mathias; Brem, Gottfried

Book ID
109828459
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
451 KB
Volume
25
Category
Article
ISSN
1061-4036

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## Background The mitochondrial DNA (mtDNA) of the cloned sheep "Dolly" and nine other ovine clones produced by somatic cell nuclear transfer (SCNT) was reported to consist only of recipient oocyte mtDNA without any detectable mtDNA contribution from the nucleus donor cell. In cattle, mouse and pig

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## Abstract Highly diverse results have been reported for mitochondrial DNA (mtDNA) hetero‐plasmy in nuclear‐transferred farm animals. In this study, we cloned genetically defined mice and investigated donor mtDNA inheritance following somatic cell cloning. Polymerase chain reaction (PCR) analysis