Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community
✍ Scribed by Prachi Mehta; George D. Mellick; Dominic B. Rowe; Glenda M. Halliday; Michael M. Jones; Neil Manwaring; Himesha Vandebona; Peter A. Silburn; Jie Jin Wang; Paul Mitchell; Carolyn M. Sue
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 321 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0885-3185
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✦ Synopsis
Abstract
MtDNA haplogroups J and K have been associated with a decreased risk of developing Parkinson's disease (PD). To confirm this finding, we compared the distribution of mtDNA haplogroups J and K in a large sample of Australian patients with PD (n = 890) to population‐based controls (n = 3,491). We assigned subjects to haplogroups J or K using standard PCR/RFLP techniques. Of the 890 subjects with PD, 10.6% were haplogroup J (95% CI 8.6–12.8, n = 94) and 7.1% were haplogroup K (95% CI 5.5–8.9, n = 63). In our controls, 10.2% belonged to haplogroup J (95% CI 9.2–11.2, n = 356), and 7.8% were in haplogroup K (95% CI 6.9–8.7, n = 272). There was no significant difference in the prevalence of mtDNA haplogroup J or K in PD patients compared to population‐based controls. Our findings indicate that mtDNA haplogroups J and K are not associated with a lower risk of PD. © 2008 Movement Disorder Society