Mitochondrial DNA disease prevalence: Still underrecognized?
β Scribed by Neil Manwaring; Jie Jin Wang; Paul Mitchell; Carolyn M. Sue
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 41 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
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Several complex disorders are suspected of being associated with mitochondrial DNA (mtDNA) mutations. We studied the statistical properties of a test based on proband-relative pairs to identify potential mtDNA mutation involvement in a complex disorder. The test compares the recurrence risk of relat
## Abstract ## Objective We studied the prevalence, segregation, and phenotype of the mitochondrial DNA 3243A>G mutation in children in a defined population in Northern Ostrobothnia, Finland. ## Methods Children with diagnoses commonly associated with mitochondrial diseases were ascertained. Blo