Mitochondrial DNA and Diseases

✍ Scribed by Hongzhi Sun, Xiangdong Wang (eds.)

• Publisher: Springer Singapore
• Year: 2017
• Tongue: English
• Leaves: 233
• Series: Advances in Experimental Medicine and Biology 1038
• Edition: 1
• Category: Library

✦ Synopsis

The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing. Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA–associated diseases.

✦ Table of Contents

Front Matter ....Pages i-vii
How Far Can Mitochondrial DNA Drive the Disease? (Hongzhi Sun, Weibin Shi, Xiangdong Wang)....Pages 1-8
Mitochondrial DNA in Lung Cancer (Fangming Liu, David E. Sanin, Xiangdong Wang)....Pages 9-22
Approach, Application, and Bioethics of mtDNA Sequencing in Cancer (Mengjia Qian, Claudio Spada, Xiangdong Wang)....Pages 23-38
Roles of Mitochondrial DNA Signaling in Immune Responses (Lingyan Wang, Michael N. Liebmen, Xiangdong Wang)....Pages 39-53
Mitochondrial DNA in Telocytes (Dongli Song, Dragos Cretoiu, Xiangdong Wang)....Pages 55-70
Roles of Mitochondrial DNA in Energy Metabolism (Jiapei Lv, Madhav Bhatia, Xiangdong Wang)....Pages 71-83
The Role of DNA Repair in Maintaining Mitochondrial DNA Stability (Linlin Zhang, Aurelio Reyes, Xiangdong Wang)....Pages 85-105
Is Mitochondrial Cell Fragility a Cell Weakness? (William Wang, Jiayuan Hou, Zhenghua Zhu, Hao Fang)....Pages 107-116
Mitochondrial DNA Methylation and Related Disease (Danyan Gao, Bijun Zhu, Hongzhi Sun, Xiangdong Wang)....Pages 117-132
Beyond Deubiquitylation: USP30-Mediated Regulation of Mitochondrial Homeostasis (Jiayun Hou, Mohmmad Eldeeb, Xiangdong Wang)....Pages 133-148
Metabolic Regulation in Mitochondria and Drug Resistance (Yue Pan, Min Cao, Jianzhou Liu, Qing Yang, Xiaoyu Miao, Vay Liang W. Go et al.)....Pages 149-171
Mitochondrial Lon Protease and Cancer (Bin Lu)....Pages 173-182
Regulatory Roles of Mitochondrial Ribosome in Lung Diseases and Single Cell Biology (Linlin Zhang, William Wang, Bijun Zhu, Xiangdong Wang)....Pages 183-200
Epithelial Mitochondrial Dysfunction in Lung Disease (Linlin Zhang, William Wang, Bijun Zhu, Xiangdong Wang)....Pages 201-217
Significance of Mitochondria DNA Mutations in Diseases (Zhenhua Zhu, Xiangdong Wang)....Pages 219-230

✦ Subjects

Cell Biology