Mitochondrial biogenesis: Which part of “NO” do we understand?

✦ Synopsis

Abstract

A recent paper by Nisoli et al.1 provides the first evidence that elevated levels of nitric oxide (NO) stimulate mitochondrial biogenesis in a number of cell lines via a soluble guanylate‐cyclase‐dependent signaling pathway that activates PGC1α (peroxisome proliferator‐activated receptor γ coactivator‐1α), a master regulator of mitochondrial content. These results raise intriguing possibilities for a role of NO in modulating mitochondrial content in response to physiological stimuli such as exercise or cold exposure. However, whether this signaling cascade represents a widespread mechanism by which mammalian tissues regulate mitochondrial content, and how it might integrate with other pathways that control PGC1α expression, remain unclear. BioEssays 25:538–541, 2003. © 2003 Wiley Periodicals, Inc.

Committee reports. Report on patent law

Committee reports. Report on patent law revision**The evidence in support of the Preambles and Resolutions and suggested additions to the copyright, patent and trade-mark laws contained in the first part of our report was not published in the May Journal owing to want of space. I am now sending you the remaining part of the report, by request, as it is considered quite necessary for the members of the Association to have in their hands before the next annual meeting, the entire document for consideration and study. It is believed that this will decidedly facilitate matters and save much time at the annual meeting which otherwise might be used up in unnecessary discussion of the subject.Your Committee wishes to again emphasize that fact that we have no desire to impose our personal views on the Association. The copyright and patent laws were designed to promote progress in science and the useful arts and the trade-mark laws to protect the public from fraud and imposition. It is generally conceded that the laws as now interpreted and applied fall short in accomplishing their purpose. It is therefore incumbent upon the A. Ph. A., representing the pharmacists of America, to suggest proper modifications of the law, of such kind as to secure the very important objects for which they were enacted.—F. E. Stewarcth, Chairman.

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