Mitochondrial ATP synthase α-subunit gene amplified in a retinoblastoma cell line maps to chromosome 18

✍ Scribed by Wenjun Bie; Jeremy A. Squire; Murray Fraser; Malcolm C. Paterson; Roseline Godbout

• Book ID: 102222277
• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 391 KB
• Volume: 14
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870140111

✦ Synopsis

The human retinoblastoma cell line Y79 has multiple copies of the MYCN gene and the DEAD box gene DOXI. Both genes have been mapped to chromosome band 2p24. A third gene, encoding the a-subunit of mitochondrial ATP synthase (ATPSA), is also amplified in W9. Here we report that there are at least four human mitochondrial ATPSA-related genes located on four different chromosomes. The ATPSA gene that is amplified in Y79 originates from chromosome 18. In W9, the amplified copies of both the ATPSA and the MYCN genes are located on a homogeneously staining region (HSR) at chromosome band lp34.