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Mitochondrial and nuclear DNA damage induced by 5-aminolevulinic acid

✍ Scribed by Janice Onuki; Yiming Chen; Priscila C. Teixeira; Robert I. Schumacher; Marisa H.G. Medeiros; Bennett Van Houten; Paolo Di Mascio


Book ID
116177174
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
702 KB
Volume
432
Category
Article
ISSN
0003-9861

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In humans, cerebral hypoxia is a common component of severe brain insults, including trauma, stroke, and perinatal asphyxia. Oxidative stress and free radicals incidental to cerebral hypoxia are implicated in damaging macromolecules, leading to collapse of cellular homeostasis and cell death. Neuron