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Mitochondrial and microsomal lipid peroxidation in rat liver after acute acetaldehyde and ethanol intoxication

✍ Scribed by Müjdat Uysal; Gül Özdemirler; Güldal Kutalp; Hikmet Öz

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
311 KB
Volume
9
Category
Article
ISSN
0260-437X

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✦ Synopsis

The effects of acetaldehyde and ethanol treatments on hepatic lipid peroxidation are compared in rats after the administration of toxically corresponding doses. Wistar rats were given a single dose of acetaldehyde (0.5 g/kg) or ethanol (5 g/kg) intraperitoneally. The animals were killed 1/2, 1, 2, 4, 6, 9, 12 and 24 h after treatments. The results indicate that acetaldehyde, like ethanol, stimulates hepatic lipid peroxidation and also selectively affects the hepatic mitochondria.

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