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Mitochondrial AIF protein involved in skeletal muscle regeneration

✍ Scribed by Xiao-zhong Qiu; Lei Yu; Gui-hua Lai; Le-yu Wang; Bing Chen; Jun Ouyang

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
197 KB
Volume
26
Category
Article
ISSN
0263-6484

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✦ Synopsis

Abstract

The mitochondrial flavoprotein apoptosis‐inducing factor (AIF) has proved to be either the main mediator of apoptosis or an anti‐apoptotic factor via its putative oxidoreductase and peroxide scavenging activities. We report here that 100 µM hydrogen peroxide (H~2~O~2~) induced the proliferation of C2C12 myoblasts and over‐expression of AIF simultaneously in vitro. Immunofluorescence showed that the over‐expression of AIF was located in the cytoplasm. The immunopositive AIF was detected in nuclei 27 days after denervation of skeletal muscle, but in the cytoplasm it was detected 27 days after fiber‐damaged skeletal muscle. AIF may be a factor involved in skeletal muscle regeneration. Copyright © 2008 John Wiley & Sons, Ltd.

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