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Mitochondrial abnormalities in selenium-deficient myopathy

✍ Scribed by Yasushi Osaki; Ichizo Nishino; Nobuyuki Murakami; Kozo Matsubayashi; Keisuke Tsuda; Yu-Ichi Yokoyama; Masanori Morita; Saburo Onishi; Yu-Ichi Goto; Ikuya Nonaka

Book ID
101250608
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
284 KB
Volume
21
Category
Article
ISSN
0148-639X

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✦ Synopsis

We report a man who developed selenium-deficient myopathy during long-term parenteral nutrition. Muscle biopsy showed marked mitochondrial depletion in the deep sarcoplasm and enlarged mitochondria at the periphery mainly in type 2 fibers. Muscle weakness improved gradually after the second course of selenium supplementation. The peculiar mitochondrial abnormalities in muscle fibers appear to play a key role in the pathogenesis of selenium-deficient myopathy.

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