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Mitochondrial abnormalities in Alzheimer disease

✍ Scribed by George Perry; Keisuke Hirai; Gjumrakch Aliev; Akihiko Nunomura; Sandra L. Siedlak; Mark A. Smith


Book ID
117412124
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
178 KB
Volume
21
Category
Article
ISSN
0197-4580

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Mitochondrial abnormalities: A primary b
✍ Mark A. Smith; Keisuke Hirai; Akihiko Nunomura; George Perry πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 125 KB πŸ‘ 3 views

The most striking feature of Alzheimer's disease (AD) is the number of abnormalities affecting essentially every aspect of brain homeostasis. Recent work suggests that increased oxidative stress that damages lipids, proteins, and nucleic acids and results in the accumulation of redox-active metals m