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Mitochondria, oxygen metabolism and the regulation of cell death

✍ Scribed by Joya Chandra; Sten Orrenius

Book ID: 117550307
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 165 KB
Volume: 1233
Category: Article
ISSN: 0531-5131
DOI: 10.1016/s0531-5131(02)00377-1

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## Abstract An increase in the permeability of the outer mitochondrial membrane is central to apoptotic cell death, since it leads to the release of several apoptogenic factors, such as cytochrome c and Smac/Diablo, into the cytoplasm that activate downstream death programs. During apoptosis, the m