Mitochondria: Aspects for neuroprotection

✍ Scribed by Paul E. Hart; Anthony H.V. Schapira

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 97 KB
• Volume: 46
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/(sici)1098-2299(199901)46:1<57::aid-ddr9>3.0.co;2-r

✦ Synopsis

The understanding of mitochondrial biology and, subsquently, the role of mitochondrial pathology in human disease has increased exponentially over the past 30 years. As insight has increased, so attention has begun to shift to the possibilities for treating mitochondrially based disorders. There are a number of archetypal mitochondrial diseases, each associated with specific mitochondrial DNA mutations, deletions, or depletions. In addition there are a number of disorders, mainly neurodegenerative in nature, in which mitochondrial dysfunction appears to play a pivotal role. Mitochondrial structure and function are discussed. Treatment of the archetypal mitochondrial disorders and other neurogenerative conditions is reviewed, with specific emphasis on the prospects for neuroprotection.