Mite serine protease activates protease-activated receptor-2 and induces cytokine release in human keratinocytes
β Scribed by T. Kato; T. Takai; T. Fujimura; H. Matsuoka; T. Ogawa; K. Murayama; A. Ishii; S. Ikeda; K. Okumura; H. Ogawa
- Book ID
- 110886817
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 462 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0105-4538
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## Abstract Adequate fluid secretion from airway mucosa is essential for maintaining mucociliary clearance, and fluid hypersecretion is a prominent feature of inflammatory airway diseases such as allergic rhinitis. House dust mite extract (HDM) has been reported to activate proteaseβactivated recep
## Background Mast cell (MC)-derived serine proteases have been implicated in a variety of inflammatory processes. We have previously shown that rat peritoneal MC (PMC) express mRNA for protease activated receptor 2 (PAR-2), a G-coupled receptor activated by trypsin-like proteases. Recent evidence