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Missense tau mutations identified in FTDP-17 have a small effect on tau–microtubule interactions

✍ Scribed by Michael DeTure; Li-wen Ko; Samuel Yen; Parimala Nacharaju; Colin Easson; Jada Lewis; Marjon van Slegtenhorst; Michael Hutton; Shu-Hui Yen

Book ID
114005444
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
756 KB
Volume
853
Category
Article
ISSN
0006-8993

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✍ Naruhiko Sahara; Takami Tomiyama; Hiroshi Mori 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 701 KB

Missense and splicing point mutations have been found in the tau gene in families with frontotemporal dementia with parkinsonism linked to chromosome 17 . Of these mutations, we examined four exonic missense point mutations (G272V, P301L, V337M and R406W) in 3-repeat or 4-repeat tau isoform on the t