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Misonidazole neuropathy: A clinical, electrophysiological and histological study

✍ Scribed by B. Melgaard; H. Sand Hansen; Z. Kamieniecka; O. B. Paulson; A. Gersel Pedersen; Xiaofu Tang; Dr. W. Trojaborg

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 667 KB
Volume: 12
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.410120103

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We studied eight patients with carcinoma of the pharynx and larynx (five cases) or lungs (three cases) who, during treatment with the radiosensitizing drug misonidazole, developed peripheral neuropathy dominated by severe sensory symptoms and signs mainly localized to the lower extremities. The symptoms partially subsided within months after cessation of therapy. Electrophysiological and histological findings indicated an axonal neuropathy with loss of large fibers and secondary demyelination. The neurotoxic property of misonidazole limits its therapeutic use.

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