Mismatch repair proteins, meiosis, and mice: understanding the complexities of mammalian meiosis
β Scribed by Anton Svetlanov; Paula E Cohen
- Book ID
- 116980990
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 321 KB
- Volume
- 296
- Category
- Article
- ISSN
- 0014-4827
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Several DNA-damage detection and repair mechanisms have evolved to repair double-strand breaks induced by mutagens. Later in evolutionary history, DNA single- and double-strand cuts made possible immune diversity by V(D)J recombination and recombination at meiosis. Such cuts are induced endogenously
## Abstract Recent discoveries have identified the small ubiquitinβlike modifier (SUMO) as the potential βmissing linkβ that could explain how the synaptonemal complex (SC) is formed during meiosis. The SC is important for a variety of chromosome interactions during meiosis and appears ladderβlike.