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Mismatch Repair Polymorphisms and Colorectal Polyps: hMLH1-93G>A Variant Modifies Risk Associated with Smoking

โœ Scribed by Yu, Joon-Ho; Bigler, Jeannette; Whitton, John; Potter, John D.; Ulrich, Cornelia M.


Book ID
120439979
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
90 KB
Volume
101
Category
Article
ISSN
0002-9270

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## Abstract Rare inherited mutations in the __mutL homolog 1__ (__MLH1__) DNA mismatch repair gene can confer an increased susceptibility to colorectal cancer (CRC) with high penetrance where disease frequently develops in the proximal colon. The core promoter of __MLH1__ contains a common single n