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Mismatch repair deficiency is associated with resistance to DNA minor groove alkylating agents

✍ Scribed by Colella, G; Marchini, S; D’Incalci, M; Brown, R; Broggini, M


Book ID
110002177
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
116 KB
Volume
80
Category
Article
ISSN
0007-0920

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## Abstract About 45% of head and neck squamous cell carcinomas (HNSCC) are characterized by amplification of chromosomal band 11q13. This amplification occurs by a breakage‐fusion‐bridge (BFB) cycle mechanism. The first step in the BFB cycle involves breakage and loss of distal 11q, from __FRA11F_