Hereditary nonpolyposis colon cancer (HNPCC) is an autosomal dominantly inherited cancer predisposition which is linked to heterozygous mutations in mismatch repair genes. HNPCC tumour cells, in which the remaining wild-type copy of the mismatch repair gene is inactivated, display instability of mic
โฆ LIBER โฆ
Mismatch repair deficiency in phenotypically normal human cells
โ Scribed by Parsons, R.; Li, G.; Longley, M.; Modrich, P.; Liu, B.; Berk, T.; Hamilton, ; Kinzler, K.; Vogelstein, B.
- Book ID
- 126541525
- Publisher
- American Association for the Advancement of Science
- Year
- 1995
- Tongue
- English
- Weight
- 909 KB
- Volume
- 268
- Category
- Article
- ISSN
- 0036-8075
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DNA mismatch repair (MMR) is essential for genome stability and inheritance of a mutated MMR gene, most frequently MSH2 or MLH1, results in cancer predisposition known as Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC). Tumors that arise through MMR deficiency show instability at
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