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MiR-181a enhances drug sensitivity in mitoxantone-resistant breast cancer cells by targeting breast cancer resistance protein (BCRP/ABCG2)

✍ Scribed by Jiao, Xuyang; Zhao, Lin; Ma, Mengtao; Bai, Xuefeng; He, Miao; Yan, Yuanyuan; Wang, Yan; Chen, Qiuchen; Zhao, Xinnan; Zhou, Mingyi; Cui, Zeshi; Zheng, Zhihong; Wang, Enhua; Wei, Minjie

Book ID
120518394
Publisher
Springer US
Year
2013
Tongue
English
Weight
898 KB
Volume
139
Category
Article
ISSN
0167-6806

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## Abstract Breast cancer resistance protein (BCRP/ABCG2) of an ATP‐binding cassette half‐transporter confers resistance against mitoxantrone and camptothecin derivatives of topotecan and irinotecan. Novobiocin, a coumermycin antibiotic, is known to enhance anticancer drug sensitivity of cancer cel