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miR-135a contributes to paclitaxel resistance in tumor cells both in vitro and in vivo

✍ Scribed by Holleman, A; Chung, I; Olsen, R R; Kwak, B; Mizokami, A; Saijo, N; Parissenti, A; Duan, Z; Voest, E E; Zetter, B R

Book ID: 109972828
Publisher: Nature Publishing Group
Year: 2011
Tongue: English
Weight: 842 KB
Volume: 30
Category: Article
ISSN: 0950-9232
DOI: 10.1038/onc.2011.148

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## Abstract Intracellular events following paclitaxel binding to microtubules that lead to cell death remain poorly understood. Because reactive oxygen species (ROS) are involved in the cytotoxicity of anticancer agents acting through independent molecular targets, we explored the role of ROS in pa