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Minor Structural Differences in Boc-CCK-4 Derivatives Dictate Affinity and Selectivity for CCK-A and CCK-B Receptors

โœ Scribed by Shiosaki, Kazumi; Lin, Chun Wel; Kopecka, Hana; Bianchi, Bruce; Miller, Thomas; Stashko, Michael; Witte, David


Book ID
126298348
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
105 KB
Volume
40
Category
Article
ISSN
0022-2623

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Conformational behavior of cyclic CCK-re
โœ P. Roy; B. Charpentier; C. Durieux; A. Dor; B. P. Roques ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 580 KB

The conformational study of a homogenous series of cyclic analogues of CCK,, selective for central receptors, such as Boc-X-Tyr(S0,H)-Nle-D-Lys-Trp-Nle-A6psp-Phe-NH,, where X = L-G~u, D-Gh, or Y-D-G~u, was performed by 4W-MHz 'H-nmr. The regular increase in affinity for central receptors when going