Minocycline in cerebral malaria

✍ Scribed by Richard E. Kast

• Book ID: 102385515
• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 32 KB
• Volume: 86
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/jnr.21791

✦ Synopsis

Recent work by two seperate groups demonstrating the critical importance of the chemokine CXCR3 for development of cerebral malaria in mice ( Van den Steen et al., 2008;Campanella et al., 2008) presents us with immediate new treatment options for children with early cerebral malaria. CXCR3 is a lymphocyte outer cell membrane receptor directing homing along a CXCL10 gradient. CXCL10 was previously termed IP-10, a 10-kDa interferon-g-inducible protein. Skin-resident plasmacytoid dendritic cells are major producers of CXCL10 after stimulation by type 1 interferons, as are CNS-resident glia (Sorensen, 2004;Tanuma et al., 2006). CNS inflammation has long been associated with CXCR3-bearing lymphocyte recruitment along a glial generated CXCL10 gradient. For example, immunohistopathology of typical multiple sclerosis plaque shows the developing rim, the lesion perimeter, rich in CXCL10 (Tanuma et al., 2006), contributing to accumulation of T cells in the CNS (Sorensen, 2004;