Repeated administration of cocaine to B6AF1/J mice increased their running response to 20 mg/kg cocaine as much as four-fold over the response to the first injection. After four daily injections, the extent of the increase was proportional to the dose of cocaine that was used for pretreatment. Sensi
β¦ LIBER β¦
Minocycline affects cocaine sensitization in mice
β Scribed by Hu Chen; Tolga Uz; Hari Manev
- Book ID
- 116771174
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 314 KB
- Volume
- 452
- Category
- Article
- ISSN
- 0304-3940
No coin nor oath required. For personal study only.
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## Abstract Activated microglia and reactive astrocytes invade and surround cerebral Ξ² amyloid (AΞ²) plaques in Alzheimer's disease (AD), but the role of microglia in plaque development is still unclear. In this study, minocycline was administered for 3 months, prior to and early in AΞ² plaque format