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Minisatellite mutation frequency in human sperm following radiotherapy

✍ Scribed by Celia A May; Keiji Tamaki; Rita Neumann; Gene Wilson; Gunar Zagars; Alan Pollack; Yuri E Dubrova; Alec J Jeffreys; Marvin L Meistrich


Book ID
114070250
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
237 KB
Volume
453
Category
Article
ISSN
0027-5107

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Frequency of minisatellite repeat number
✍ Ningjia Zheng; Darren G. Monckton; Gene Wilson; Fredrick Hagemeister; Ranajit Ch πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 114 KB

To determine whether the measurement of repeat number mutations at a minisatellite locus could detect human germline mutations induced by chemotherapy, we performed a longitudinal study of the mutation frequencies in sperm from 10 patients treated for Hodgkin's disease. Polymerase chain reaction on