Minireview: Nonsteroidal anti-inflammatory drugs in colorectal cancer: from prevention to therapy
โ Scribed by Ricchi, P; Zarrilli, R; di Palma, A; Acquaviva, A M
- Book ID
- 109997517
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 107 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0007-0920
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## Background Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to be effective in inhibiting colorectal cancer. Cyclooxygenase activity is thought to mediate, in part, this cancer preventive effect. From observations made when cells that express cyclooxygenase activity were treated wit
## Abstract Genistein is an isoflavenoid found in soy that has antiโtumorigenic activities. Treatment of colorectal carcinoma HCTโ116 cells with 50 ฮผM genistein results in a 50% reduction in cell proliferation and a 6โfold increase in apoptosis. Genistein induces nonsteroidal antiโinflammatory drug