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Minimizing the damage: repair pathways keep mitochondrial DNA intact

✍ Scribed by Kazak, Lawrence; Reyes, Aurelio; Holt, Ian J.

Book ID
115485409
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
893 KB
Volume
13
Category
Article
ISSN
1471-0072

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## Abstract Oxidative damage represents the most significant insult to organisms because of continuous production of the reactive oxygen species (ROS) in vivo. Oxidative damage in DNA, a critical target of ROS, is repaired primarily via the base excision repair (BER) pathway which appears to be the