Minimal residual disease is an important predictive factor of outcome in children with relapsed ‘high-risk’ acute lymphoblastic leukemia
✍ Scribed by Paganin, M; Zecca, M; Fabbri, G; Polato, K; Biondi, A; Rizzari, C; Locatelli, F; Basso, G
- Book ID
- 109886587
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 149 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0887-6924
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One hundred fourteen children with acute lymphoblastic leukemia were treated with allogeneic marrow transplantation from HLAidentical siblings after conditioning with cyclophosphamide and total body irradiation. Methotrexate was given posttransplantation for prophylaxis of graft-versus-host disease.
## Abstract ## Background: Multiparameter flow cytometry (MFC) has been shown to be a useful approach for detection of minimal residual disease (MRD). The aim of the study was to determine the optimal threshold that can separate patients into two groups in terms of leukemic residual cells and rela