Mineralized Collagen Bone Graft Substitutes

✍ Scribed by Cui, Fu-Zhai(Editor);Cui, Yun(Editor);Qiu, Hi-Ye(Editor)

• Publisher: Woodhead Publishing
• Year: 2019
• Tongue: English
• Leaves: 259
• Category: Library

✦ Synopsis

Mineralized Collagen Bone Graft Substitutespresents a comprehensive study of biomimetic mineralized collagen, synthesized in vitro, a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the clinical use of this novel material, the book provides a complete examination, from bench to bedside. Chapters discuss natural bone and familiar biomaterials for bone repair, the preparation and safety of mineralized collagen, products made of mineralized collagen, and present clinical case studies. This book is an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry.

✦ Table of Contents

Front Cover......Page 1
Mineralized Collagen Bone Graft Substitutes......Page 4
Copyright Page......Page 5
Contents......Page 6
List of Contributors......Page 12
Preface......Page 14
1.1.1.1 Inorganic Minerals......Page 16
1.1.1.3 Osteocytes......Page 17
Osteoprogenitors......Page 19
Osteoblasts......Page 20
1.1.2 Bone Structure......Page 21
1.2.1.1 Membrane Osteogenesis......Page 23
1.2.1.2 Cartilage Osteogenesis......Page 24
1.2.2 Fracture Healing and Bone Remodeling......Page 25
1.3 Bone Defect Repair Materials......Page 27
1.3.1 Bone Tissue Engineering......Page 28
1.3.2 Bone Defect Repair Materials......Page 31
1.3.2.4 Synthetic Polymeric Materials......Page 32
HA/Natural Biopolymer......Page 33
Porous......Page 34
Degradation......Page 35
References......Page 36
2.1 The Basic Principles of Biomineralization......Page 38
2.1.1 Biological Mineralization Interface Control......Page 40
2.1.2 Natural Bone Formation and Mineralization......Page 41
2.2.1 Hierarchical Structure......Page 43
2.2.2 Prebuilt......Page 46
2.2.3 Highly Ordered Self-assembly......Page 47
2.3.1 Ball......Page 49
2.3.2 Construction Phase......Page 52
2.4 Mineralized Collagen Nanofibers Multilevel Self-assembly and its Application in the Regeneration of Bone Engineering......Page 54
2.4.1 Transmission Electron Microscopy......Page 55
2.4.2 Scanning Electron Microscopy......Page 57
2.4.3 Crystal Structure......Page 58
2.5.1 General Observation and Density Measurements......Page 60
2.5.3 High-Strength Mineralized Collagen Molecular Structure......Page 61
2.5.4 The Microstructure of High-Strength Mineralized Collagen......Page 62
2.5.6 In Vitro Biocompatibility......Page 63
2.5.7 In Vivo Biocompatibility and Stability Evaluations......Page 65
2.6 Common Market Mineralized Collagen Material......Page 66
References......Page 73
3.1 Cell Response to the Material......Page 76
3.1.3 Cell Proliferation and Differentiation......Page 77
3.2.1.1 Material......Page 78
3.2.1.2 Method: Mesenchymal Stem Cell Phenotype......Page 79
3.2.1.3 Results......Page 80
3.2.1.4 Conclusion......Page 81
3.2.2.1 Materials and Methods......Page 82
3.2.2.3 Conclusion......Page 84
3.3.1.1 Experimental......Page 87
3.3.1.2 Results......Page 89
3.3.2.1 Materials and Methods......Page 101
3.3.2.2 Results......Page 103
3.3.2.3 Conclusion......Page 104
3.3.3.1 Materials and Methods......Page 105
3.3.3.2 Results......Page 106
3.3.3.3 Discussion......Page 108
3.4 Biological Evaluation......Page 110
References......Page 112
4.1.1 Objective......Page 114
4.1.3 Experiment Result......Page 115
4.1.5 Conclusion......Page 117
4.2.2.3 Study Materials......Page 119
4.2.2.5 Study Observations......Page 120
4.2.3.1 Gross Observations......Page 122
4.2.3.3 Histological Observation......Page 123
4.2.3.4 Mechanical Testing......Page 125
4.2.4 Discussion......Page 126
4.3.1 Objective......Page 127
4.3.2.4 Methods......Page 128
4.3.3.1 Manual Palpation......Page 129
4.3.3.3 Histologic Analysis......Page 130
4.3.3.4 Mechanical Strength......Page 133
4.4.1 Objective......Page 134
4.4.2.3 Methods......Page 135
4.4.3.3 Histological Observation......Page 136
4.4.4 Conclusions......Page 138
4.5.2.2 Methods the Experiment Groups......Page 139
4.5.4 Discussion......Page 140
4.6.1 Experiment Purpose......Page 142
4.6.2.5 Experimental Observation......Page 143
4.6.3.3 Histological Observation......Page 144
4.6.4 Discussion......Page 145
4.7.1 Experiment Purpose......Page 146
4.7.2.5 Experimental Observation......Page 147
4.7.3.3 Histological Observation......Page 148
4.7.3.4 Statistics......Page 150
4.7.5 Conclusion......Page 151
4.8.2.4 Experimental Methods......Page 152
4.8.2.5 Experimental Observation......Page 153
4.8.3.1 Gross Observation......Page 154
4.8.3.2 Imaging Observation......Page 155
4.8.3.3 Histological Observation......Page 158
4.8.4 Discussion......Page 159
4.9.2.3 Materials......Page 161
4.9.3.2 Histological Observation......Page 162
4.9.4 Discussion......Page 166
4.10.2.2 Group of Experiments......Page 167
4.10.2.5 Observation......Page 168
4.10.3.2 Bone Density Measurement......Page 169
4.10.5 Results......Page 171
4.11.2.3 Experimental Observation......Page 173
4.11.3 Results......Page 174
4.11.4 Discussion......Page 176
4.11.5 Conclusion......Page 179
References......Page 180
5 Clinical Applications of the Mineralized Collagen......Page 182
5.1.2 Typical Case 2: Atlanto-Axial Intertransverse Fusion......Page 183
5.1.3 Typical Case 3: Lumbar Interbody Fusion......Page 184
5.1.5 Typical Case 5: Lumbar Interbody Fusion......Page 185
5.1.6 Typical Case 6: Lumbar Interbody Fusion......Page 186
5.1.7 Typical Case 7: Lumbar Interbody Fusion......Page 187
5.2 Clinical Applications of the Mineralized Collagen in Intertransverse Fusion......Page 188
5.2.1 Typical Case 1: Lumbar Intertransverse Fusion......Page 189
5.2.3 Typical Case 3: Lumbar Intertransverse Fusion......Page 190
5.2.5 Typical Case 5: Lumbar Intertransverse Fusion......Page 191
5.2.6 Typical Case 6: Lumbar Intertransverse Fusion......Page 193
5.3.1 Typical Case 1......Page 194
5.3.2 Typical Case 2......Page 196
5.4.2 Typical Case 2: Comminuted Fracture at Right Olecroanon......Page 197
5.4.3 Typical Case 3: Osteoporotic Proximal Humeral Fractures......Page 198
5.4.5 Typical Case 5: Middle Femoral Shaft Comminuted Fracture......Page 200
5.4.6 Typical Case 6: Fracture of Tibial Plateau......Page 201
5.4.7 Typical Case 7: Fracture of Tibial Plateau......Page 202
5.4.8 Typical Case 8: Fibula Comminuted Fracture......Page 203
5.4.9 Typical Case 9: The Disconnection of Limb Bones......Page 204
5.4.11 Typical Case 11: Intraarticular Calcaneal Fractures......Page 206
5.4.12 Typical Case 12: Lateral Malleolus Fracture......Page 208
5.4.14 Typical Case 14: Flat Foot......Page 210
5.5.1 Typical Case 1: The Repair of Fractured Acetabular After 4 Years of THA......Page 212
5.5.2 Typical 2: Acetabulum and Femoral Prosthesis Loosen After THA......Page 213
5.6 The Mineralized Collagen Used for the Treatment of Adult Early Necrosis of Femoral Head......Page 214
5.6.2 Typical Case 2......Page 215
5.6.4 Typical Case 4......Page 217
5.7.2 Case 2: Tibial Plateau Cyst......Page 220
5.7.3 Case 3: Bone Cyst of the Middle Part of the Humerus......Page 221
5.7.4 Case 4: Fibrous Dysplasia of Bone......Page 223
5.8 Vertebral Compression Fractures by Using Mineralized Collagen Modified Bone Cement......Page 224
5.8.1 Case 1......Page 225
5.8.2 Case 2......Page 226
5.8.3 Case 3......Page 227
5.8.4 Case 4......Page 228
5.9.1 Case 1......Page 230
5.9.2 Case 2......Page 233
5.9.4 Case 1......Page 236
5.10 The Application of Mineralized Collagen Bone Powder and GTR Membrane in Bone Graft After Curettage of Apical Cyst......Page 237
5.11 The Application of Mineralized Collagen in Bone Graft After Curettage of Chronic Periapical Periodontitis......Page 238
5.12 Regenerative Repair of Cranium Bone Defect With Mineralized Collagen......Page 239
5.12.1 Case 1......Page 240
5.12.2 Case 2......Page 241
5.12.3 Case 3......Page 242
5.12.4 Case 4......Page 243
5.12.5 Case 5......Page 244
References......Page 246
Index......Page 248
Back Cover......Page 259