Millisecond Time-lapsed Monitoring of ATP Hydrolysis by Human Eg5 Kinesin: Real-time Dynamics of Conformation and Chemistry in vitro

Real-Time Monitoring of Metabolic Reacti

Real-Time Monitoring of Metabolic Reactions by Microdialysis in Combination with Tandem Mass Spectrometry: Hydrolysis of CS-866 in Vitro in Human and Rat Plasma, Livers, and Small Intestines

✍ Nobuhiro Kobayashi; Izumi Fujimori; Misa Watanabe; Toshihiko Ikeda 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 91 KB

Microdialysis combined with tandem mass spectrometry was used to monitor the rapid hydrolysis of CS-866, a new prodrug-type angiotensin II receptor antagonist, in vitro in rat and human plasma as well as in hepatic and intestinal preparations. No chromatographic separation was conducted, and the ion