✦ LIBER ✦
Mild non-enzymatic hydrolysis of an ester bond between the orthophosphoric acid and ethanolamine residues in phosphatidylethanolamines
✍ Scribed by Anatoly V Zhukov; Elmira I Kusnetsova; Andrei G Vereshchagin
- Book ID
- 103038445
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 397 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0009-3084
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✦ Synopsis
Acetylation of phosphatidylethanolamine (PE) yielding its N-acetamide (AcPE) brings about changes in the charge and conformation of the polar head group. As a result, the P O-C bond of AcPE can be hydrolysed, with the formation of ethanolamine (EA) N-acetamide (AcEA), under much more mild conditions than the respective bond in the original PE. Thus, introduction of an acyl substituent into the PE amino moiety exerts a profound effect on the course of hydrolysis of the PE P-O C bond separated from this moiety by two CH 2 segments.