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Mild hypoxia-induced cardiomyocyte hypertrophy via up-regulation of HIF-1α-mediated TRPC signalling

✍ Scribed by Wenfeng Chu; Lin Wan; Dan Zhao; Xuefeng Qu; Fulai Cai; Rong Huo; Ning Wang; Jiuxin Zhu; Chun Zhang; Fangfang Zheng; Ruijun Cai; Deli Dong; Yanjie Lu; Baofeng Yang

Book ID: 119857604
Publisher: Carol Davila University of Medicine Bucharest, Romania
Year: 2012
Tongue: English
Weight: 852 KB
Volume: 16
Category: Article
ISSN: 1582-1838
DOI: 10.1111/j.1582-4934.2011.01497.x

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## ABSTRACT Cigarette smoking is strongly implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mucus hypersecretion is the key manifestation in patients with COPD and mucin 5AC (MUC5AC) is a major component of airway mucus. Hypoxia inducible factor‐1 (HIF‐1) is a transcri