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Mild hyperhomocysteinemia, C677T polymorphism on methylenetetrahydrofolate reductase gene and the risk of macroangiopathy in type 2 diabetes: a prospective study

✍ Scribed by Giuseppina Tiziana Russo; Antonino Di Benedetto; Domenico Magazzù; Annalisa Giandalia; Carlo Bruno Giorda; Riccardo Ientile; Marcello Previti; Enrico Di Cesare; Domenico Cucinotta

Book ID: 111707305
Publisher: Springer
Year: 2009
Tongue: English
Weight: 201 KB
Volume: 48
Category: Article
ISSN: 0940-5429
DOI: 10.1007/s00592-009-0169-5

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## Abstract ## Background Poor glycaemic control, hypertension and duration of diabetes are risk factors for the development of diabetic nephropathy, but there may be genetic factors. Recently, a common C to T mutation at nucleotide position 677 of the MTHFR gene (MTHFR677C > T) has been reported