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Mild deprotection of methoxymethyl, methylthiomethyl, methoxyethoxymethyl, and and β-(trimethylsilyl,)ethoxymethyl, esters with magnesium bromide in ether

✍ Scribed by Sunggak Kim; Young Hee Park; In Seo Kee


Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
133 KB
Volume
32
Category
Article
ISSN
0040-4039

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Mild, selective cleavage of amino acid a
✍ Wei-Chuan Chen; Matthew D. Vera; Madeleine M. Joullié 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 237 KB

Magnesium bromide etherate has been previously shown to cleave p-(trimethylsilyl)ethoxymethyl (SEM) esters of aliphatic acids. This methodology has now been extended to amino acid and peptide derivatives in the presence of protecting groups typically encountered in peptide chemistry, including the B