Mild, selective cleavage of amino acid a
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Wei-Chuan Chen; Matthew D. Vera; Madeleine M. Joullié
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Article
📅
1997
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Elsevier Science
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French
⚖ 237 KB
Magnesium bromide etherate has been previously shown to cleave p-(trimethylsilyl)ethoxymethyl (SEM) esters of aliphatic acids. This methodology has now been extended to amino acid and peptide derivatives in the presence of protecting groups typically encountered in peptide chemistry, including the B