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Mild and practical stereoselective synthesis of (Z)- and (E)-allyl bromides from Baylis–Hillman adducts using Appel agents (PPh3/CBr4): a facile synthesis of semiplenamides C and E

✍ Scribed by Biswanath Das; Kongara Damodar; Nisith Bhunia; Boddu Shashikanth


Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
223 KB
Volume
50
Category
Article
ISSN
0040-4039

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✦ Synopsis


Appel agents (PPh 3 /CBr 4 ) have been utilized for high-yielding stereoselective synthesis of (Z)-and (E)allyl bromides from Baylis-Hillman adducts at room temperature. The method has been applied for the synthesis of naturally occurring bioactive fatty acid amides, semiplenamides C and E.


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