✦ LIBER ✦
Mild air-oxidation of 1,3-dicarbonyl compounds with cesium salts: Novel α-hydroxylation accompanied by partial hydrolysis of malonate derivatives
✍ Scribed by Toshiko Watanabe; Tsutomu Ishikawa
- Book ID
- 104262396
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 231 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
1,3-Dicarbonyl eompomids (1) were efficiently oxygetmted at the or-position with cesium salts, such as CsF or Cs2CO3 (0. l Meq) ill DMF at room temperature. Reaction of malonate derivatives (la, b) with excess amount (2 Meq) of Cs2CO3 gave ~t-hydroxyhnonoester (3) formed by oxygenation and partial hy&olysis, which was decarboxylated to a lactic acid derivative (5).