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Mikrobielle Reduktion 2,2-disubstituierter Cyclopentan-1,3-dione. Darstellung chiraler Cyclopentanderivate für die Synthese von 8-Methyl-prostaglandinen

✍ Scribed by Dr. S. Schwarz; Dr. G. Truckenbrodt; Chem. Ing. M. Meyer; Dr. R. Zepter; Chem. Ing. Gisela Weber; Dipl.-Chem. Constanze Carl; Dipl.-Phys M. Wentzke; Prof. Dr. H. Schick; Dipl.-Chem. H.-P. Welzel

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 504 KB
Volume: 323
Category: Article
ISSN: 1615-4150
DOI: 10.1002/prac.19813230505

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✦ Synopsis

Microbial Reduction of 2,2‐Disubstituted Cyclopentan‐1,3‐diones. Synthesis of Chiral Cyclopentane Derivatives Useful as Intermediates for 8‐Methyl Prostaglandins

The microbial reduction of the 2,2‐disubstituted cyclopentan‐1,3‐diones 3ac giving rise to the chiral compounds 2, 4b and 4c is described.

The incubation products can be used as intermediates for 8‐methyl prostaglandins.

The structures of the fermentatively formed compounds, including their chirality and optical purity have been established by comparison with authentic specimen (cp. 2) or by chemical and spectroscopic methods (cp. 4b, 4c) respectively.

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