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Migratory Dendritic Cells Transfer Antigen to a Lymph Node-Resident Dendritic Cell Population for Efficient CTL Priming

✍ Scribed by Rhys S. Allan; Jason Waithman; Sammy Bedoui; Claerwen M. Jones; Jose A. Villadangos; Yifan Zhan; Andrew M. Lew; Ken Shortman; William R. Heath; Francis R. Carbone


Book ID
116570609
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
372 KB
Volume
25
Category
Article
ISSN
1074-7613

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The EBV-encoded LMP2A protein is consistently expressed in EBV(+) Hodgkin's lymphoma and can be targeted by CTLs. CTLs stimulated conventionally by LCLs have little activity against LMP2A(+) target cells. Here, we describe an alternative approach, based on the in vitro stimulation of CTLs with DCs g