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Migratory and proliferative effect of platelet-derived growth factor in rabbit retinal endothelial cells: Evidence of an autocrine pathway of platelet-derived growth factor

✍ Scribed by Noriyuki Koyama; Satoe Watanabe; Mariko Tezuka; Nobuhiro Morisaki; Yasushi Saito; Sho Yoshida

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
695 KB
Volume
158
Category
Article
ISSN
0021-9541

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✦ Synopsis

Angiogenesis is a crucial event in the progression of diabetic retinopathy. Migration and proliferation of endothelial cells (EC) are important steps in angiogenesis and are caused by angiogenic factors such as basic fibroblast growth factor (bFGF). In this work, capillary EC were isolated from rabbit retinal tissues and rabbit retinal EC (RREC) were found to secrete a migration factor for RREC in conditioned medium (CM). The activity was inhibited by an anti-platelet-derived growth factor (PDGF) antibody, but not by an anti-bFGF antibody. We also found that RREC showed a migratory response to PDGF.

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