Migration of naive and memory T cells in vivo

✍ Scribed by Jürgen Westermann; Ulrike Bode; Reinhard Pabst

• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 236 KB
• Volume: 19
• Category: Article
• ISSN: 0167-5699
• DOI: 10.1016/s0167-5699(98)80015-7

✦ Synopsis

The prominent role that PGE could play in anergy induction in decidua might also be exercised following semen deposition in the lower female genital tract, leading to T cells that are specifically anergic to spermatozoal antigen 12. This would support the adage that Nature is economical with her mechanisms. The presentation of such antigens in the vagina and cervix would unavoidably be affected by the vast concentrations of PGE in human seminal plasma.

Thus, studies of early decidua, trophoblast and human seminal plasma lead to the conclusion that PGE is a major modulator of the immune response in reproduction. Moreover, not only may PGE be the overriding inducer of the shift to the Th2 cytokine pattern but also, and perhaps most relevant, a state of anergy in T cells.