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Migraine and MTHFR C677T genotype in a population-based sample

✍ Scribed by Ann I. Scher; Gisela M. Terwindt; W. M. Monique Verschuren; Mark C. Kruit; Henk J. Blom; Hisanori Kowa; Rune R. Frants; Arn M. J. M. van den Maagdenberg; Mark van Buchem; Michel D. Ferrari; Lenore J. Launer

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 75 KB
Volume: 59
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.20755

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Objective

Migraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status.

Methods

We compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population‐based Genetic Epidemiology of Migraine study.

Results

Compared with the wild‐type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2–3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1–1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine.

Interpretation

Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors. Ann Neurol 2006

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