Microwave-mediated synthesis and antibacterial activity of some novel 2-(substituted biphenyl) benzimidazoles via Suzuki-Miyaura cross coupling reaction and their N-substituted derivatives

✍ Scribed by Changdev Namdev Raut; Shailendra Mitharam Bharambe; Yogesh Ashok Pawar; Pramod Pandurang Mahulikar

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2011
• Tongue: English
• Weight: 123 KB
• Volume: 48
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.610

✦ Synopsis

Abstract

A series of some novel 2‐(substituted biphenyl) benzimidazoles and their N‐substituted derivatives were synthesized via microwave‐mediated Suzuki‐Miyaura coupling of 2‐(4‐iodophenyl)‐1__H__‐benzimidazole or 2‐(4‐iodophenyl)‐6‐amino‐1__H__‐benzimidazole and arylboronic acids. The method reported herein offers advantageous shorter reaction times, higher yields and is applicable to a large set of substrates. All the synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus and Salmonella typhimurium bacterial species. J. Heterocyclic Chem., (2011).