Microwave irradiation and instrumental behavior in rats: Unitized irradiation and behavioral evaluation facility

✍ Scribed by Dr. R. M. Lebovitz; R. L. Seaman

• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: English
• Weight: 754 KB
• Volume: 1
• Category: Article
• ISSN: 0197-8462
• DOI: 10.1002/bem.2250010408

✦ Synopsis

Abstract

A facility for the exposure of small animals to pulse‐modulated microwave radiation (PM MWR) concurrent with their performance of operant behavioral tasks is described. The computer‐managed facility comprises an array of 32 individual waveguide exposure cells, each enclosing instrumental conditioning apparatus within a plastic subhousing. The distribution of the microwave electric field intensity within the waveguide was measured by a nonperturbing probe and the modifications induced by the behavioral apparatus and animal within the waveguide determined. Input and interior voltage standing wave ratios are presented to characterize the design of the chambers and to demonstrate the suitability of the chambers for whole‐body irradiation of rat. The specific absorption rate (SAR) is presented utilizing data derived from incremental thermometric examination of saline loads and of selected sites in rat carcasses. This is compared with the whole‐body SAR derived from the input/ output energy balance equation for the waveguide. The results of continuous monitoring of the SAR by the latter method, while unrestrained rats were engaged in operant and exploratory behavior within the waveguide, are utilized to derive a relationship between chamber input power and the dose rate for adult rats behaviorally active within the waveguide. From these data, we conclude that the experimental array provides a practical method for exposing a large number of animals to PM MWR for long periods of time and coincident with the establishment and/or performance of complex operant behavior.