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Microwave Induced Synthesis and Antibacterial Activity of Cephalosporin Derivatives Using Solid Support

✍ Scribed by Mazaahir Kidwai; Pooja Sapra; Kumar Ranjan Bhushan; Preeti Misra; Rajendra K. Saxena; Rani Gupta; Meena Singh

Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
71 KB
Volume
29
Category
Article
ISSN
0045-2068

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✦ Synopsis

Reaction of 7-amino-3-[5Ј-methyl-1Ј,3Ј,4Ј-thiadiazol-2Ј-ylthiomethyl]cephalo-sporanic acid with heterocyclic amines using basic alumina under microwave irradiation (MWI) afforded new cephalosporin analogs in shorter reaction time with improved yield as compared to conventional heating. All the synthesised compounds were tested for their in vitro antibacterial activity, using cefotaxime and cephalothin as reference drugs. All compounds showed significant in vitro antibacterial activity against E. herbicola, P. vulgaries, and Z. mobilis. ᭧ 2001 Elsevier Science (USA)

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