Microwave-assisted synthesis of α-aminophosphinic acids from hypophosphorus acid salts under solvent free conditions

✍ Scribed by Babak Kaboudin; Nasser As-habei

• Book ID: 104253638
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 72 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)00893-1

✦ Synopsis

A simple, efficient, and general method has been developed for the synthesis of a-aminophosphinic acids from hypophosphorus salts under solvent-free conditions using microwave irradiation. a-Aminophosphinic acids were obtained in high yield under mild conditions by reaction of the amine salts of hypophosphorus acid with aldehydes in the presence of microwave irradiation.