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Microwave assisted synthesis of thiazolo[3,2-b][1,2,4]-triazoles containing 1,8-naphthyridine moiety

✍ Scribed by K. Mogilaiah; M. Prashanthi; S. Kavitha; H. Sharath Babu


Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
181 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

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A simple and efficient protocol for the synthesis of 5‐aryl‐2‐(2‐substituted‐1,8‐naphthyridin‐3‐yl)‐thiazolo[3,2‐b][1,2,4]triazoles (4) is achieved by cyclocondensation of 3‐(2‐substituted‐1,8‐naphthyridin‐3‐yl)‐1,2,4‐triazoles (3) with α‐halogenoketones in anhyd. methanol under microwave irradiation. The products are obtained in good yields and in a state of high purity.


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