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Microwave assisted synthesis of chiral imidazolyl and pyrazolyl alcohols

✍ Scribed by Holger Glas; Werner R. Thiel

Book ID
104259575
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
104 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

Microwave assisted ring opening of (R)-styrene epoxide with pyrazole and imidazole gives the corresponding (RI-configurated (1-phenyl)(2-azolyl)ethanols in high yields. In the case of pyrazote, the application of microwave heating increases both, cbemo-and regioselectivity compared to conventional heating methods.

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## Abstract **Summary:** Chiral (__R__)‐__N__‐(1‐phenylethyl)‐acrylamide (**3**) was synthesized directly from acrylic acid (**1**) and (__R__)‐1‐phenylethylamine (**2**) via microwave irradiation without any further activation and in a solvent‐free medium. The kinetic measurements performed show h