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Microwave assisted synthesis of 5-hydroxy-5-trichloromethyl-4,5-dihydroisoxazoles

✍ Scribed by Marcos A.P Martins; Paulo Beck; Wilson Cunico; Claudio M.P Pereira; Adilson P Sinhorin; Rogério F Blanco; Rodrigo Peres; Helio G Bonacorso; Nilo Zanatta

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
137 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

A series of 13 5-hydroxy-5-trichloromethyl-4,5-dihydroisoxazoles have been synthesized in 78-96% yield by environmentally benign microwave induced techniques involving the cyclocondensation of 4-alkoxy-1,1,1-trichloro-3-alken-2-ones [CCl 3 C(O)C(R 2 )=C(R 1 )OR, where R 2 =H, alkyl; R 1 =H, alkyl, aryl and R=H, alkyl] with hydroxylamine using toluene as solvent. The advantages obtained by the use of microwave irradiation in relation to a classical method were demonstrated.

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